Intriguingly, we also observed that the expression of PTPRκ is inversely correlated with expression of LYPLA1/APT1 (Supplementary Figure 8A), which is significantly upregulated in melanoma39 (Supplementary Figure 8B), suggesting that deregulation of the N/HRAS palmitoylation cycle in melanoma cells could be responsible for reduced PTPRκ expression. Here, HRAS is linked to melanoma.