[3, 17, 19–22] Exposure of cells derived from a panel of solid tumors, including non-small cell lung carcinoma (H1299 and A549), pancreas (SUIT-2), colon (HCT116 and HT-29) and prostate cancer (PC-3) to a combination of S63845 or A-1331852 resulted in a marked induction of apoptosis, confirming that these cell lines depend on both BCL-XL and MCL-1 for survival (Fig. 3a). This evidence concerns the gene MCL1 and non-small cell lung carcinoma.