Furthermore, we also studied the levels of expression of SphK1 and SphK2 in PBMCs of patients affected by spondyloarthritis, a disease typically associated to Th17 subset20, observing a correlation between the percentage of IL-17 producing cells, identified as CD4+/CD161+ double positive cells19,20, and the expression levels of SphKs. The gene discussed is IL17A; the disease is spondyloarthropathy.