APOE genotype was not associated with subject scores determined by GLM or SSM/PCA (p > 0.16, student t-test), but significantly more proportion of stable MCI patients had APOE ɛ4 allele when they were designates as AD than non-AD by both SVM methods (p < 0.007, chi-square; Fig. 4B). The gene discussed is APOE; the disease is Alzheimer disease.