Nevertheless, it is of interests that only the SVM’s AD designation was associated with APOE genotype in stable MCI, which is in agreement with the APOE ɛ4 status being one of the most significant risk factor for AD43, e.g., only 31 of 111 normal controls (28%) were ɛ4 carrier in contrast to 46 of 74 AD patients (61%). The gene discussed is APOE; the disease is Alzheimer disease.