BBC3 and infection: PMUA, (p53 Upregulated modulator of apoptosis) (PUMA), a Bcl-2 homology 3 (BH3)-only Bcl-2 family member, plays an essential role in p53-dependent and -independent cell apoptosis induced by a variety of stimuli, including inhibited de-regulated oncogene expression, genotoxic stress, growth factor/cytokine withdrawal and infection, toxins, altered redox status8–12.