Assessing the protein profiles of large and small neoplastic islands and their surrounding stroma by combining laser microdissection (LMD) and proteomics reveals several proteins—including CSTB, NDRG1, LTA4H, PGK1, COL6A1, ITGAV, and MB—with distinct expression patterns between ITF and inner tumor, suggesting a potential prognostic value by clinicopathological association analysis. The gene discussed is ITGAV; the disease is neoplasm.