The majority of proteins (ACTR2, CSTB, LTA4H, PGK1, NDRG1, FSCN1, ITGAV, THBS2) significantly associated with clinical parameters showed lower expression in the ITF of the tumor stroma or neoplastic islands, with the exception of COL6A1, COL1A2, S100A8, S110A9, and MB. This evidence concerns the gene S100A8 and neoplasm.