Here we indicate a robust prognostic signature with CSTB, at low protein expression levels in the ITF, as an independent marker for local recurrence; and with the combination of LTA4H-, COL6A1-, and CSTB-specific peptides in saliva, able to distinguish patients with and without lymph node metastasis. This evidence concerns the gene LTA4H and metastatic malignant neoplasm in the lymph nodes.