TEK and brain ischemia: In the current study, we found that α5β1 integrin co-localized with Tie2/P-Tie2 on the cerebral vessels in the ischemic penumbra after focal cerebral ischemia, showing that there is a direct interaction between α5β1 integrin and Tie2, and that α5β1 integrin might be related to the activation of Tie2 after cerebral ischemia.