DGM-17 and DGM-5 contain 109 and 291 genes, respectively, including VRK2, OPRM1, and TCF7L2 in DGM-17; AKT1, CREB1, CALB1, FAS, FKBP4, FOXP3, HDAC5, and PDE6C in DGM-5, which, as we discuss below, are components of pathways potentially related to mood disorders. The gene discussed is TCF7L2; the disease is mood disorder.