The 14 low-expression genes have been associated with epilepsy, including: ARG1 [24–27], ARHGEF15 [28], CASR [29, 30], CHRNA2 [31], DBH [32–34], DIAPH3 [35], FOLR1 [36, 37], GABRA6 [38, 39], GLRA1 [40, 41], NID2 [42, 43], PROC [44], SLC13A5 [45, 46], SLC19A3 [47], SRPX2 [48]. The gene discussed is ARHGEF15; the disease is epilepsy.