FMO5 and cardiovascular disorder: The close relationship between inflammation and oxidative damage [6, 15, 22, 63] is supported by previous studies from our group demonstrating that virtually all cells from classical target organs of cardiovascular diseases are affected by ROS overproduction [7, 15, 20–23, 64, 65], mainly by the NADPH oxidases, which also are the main sources of ROS in phagocytic cells [66].