SOD1 and Myocardial fibrosis: Doxorubicin can further elevate cardiomyocyte apoptosis and left ventricular fibrosis and inflammatory cell infiltration in EC-SOD knockout mice, whereas AEOL-10150 eliminates cardiac dysfunction and myocardial fibrosis in doxorubicin-induced wild-type mice and EC-SOD knockout mice [56].