Knockdown of LSD-1 (KDM1) and JARID1B (KDM5B) that mediate demethylation of mono-, di-, and trimethylated H3K4, or the histone lysine methytransferase KMT6 that mediateds trimethylation of H3K27 significantly enhanced DAC-mediated activation of MAGE-A genes in lung cancer cells [70]. The gene discussed is KDM1A; the disease is lung cancer.