In the present study, we investigated the in vivo activity of anti-immune CPI-based therapies against TNBC PDX tumor models established in models of “humanized” nonobese diabetic/severe combined immunodeficiency IL2Rγnull (hNSG) mice by the engraftment of human CD34+ HSCs, as previously described [28, 29]. Here, CD34 is linked to neoplasm.