E2F5 and posterior cortical atrophy: In our study, it was suggested that miR-1-3p binds to a complementary site, which is conserved among most vertebrates on the 3′-UTR of E2F5 and PFTK1, resulting in down-regulation of its target genes E2F5 and PFTK1 expression in PCa cells, as determined by luciferase assays and Western blot analyses.