CDK14 and posterior cortical atrophy: To further explore whether miR-1-3p targeting of E2F5 and PFTK1 is responsible for inhibiting proliferation and cell cycle progression of PCa cells, we performed loss-of-function experiments by co-transfecting siE2F5/siPFTK1 or control along with the miR-1-3p inhibitor or inhibitor-NC into LNcaP cells.