Furthermore, we detected the expression of HMGCR (3-hydroxy-3-Methylglutaryl -coenzyme A) in the tissues, and the results showed that the expression of HMGCR was also higher in carcinomatous tissues than that of the distal normal tissues in 12 pairs of colon cancer tissues (Additional file 6: Figure S5). The gene discussed is HMGCR; the disease is malignant colon neoplasm.