HLA-DRB1 and myeloid sarcoma: We previously reported that MS patients with HLA-DRB1*04:05, one of the strongest and most common susceptibility alleles for MS in Japanese individuals, but which is rare in general European populations, showed decreased Barkhof criteria fulfillment and fewer intracortical lesions compared with those without DRB1*04:05 [10, 31, 32].