INS and type 2 diabetes mellitus: Experimental evidence supports the biological plausibility of beneficial effects of PUFAs, particularly PUFAs that are predominantly ω-6 LA, on several mechanisms associated with insulin sensitivity and the development of T2D, including, but not limited to, suppressing hepatic lipogenesis, steatosis, and pancreatic lipotoxicity, as well as dampening the toxicity of tissue FFAs, increasing membrane fluidity, positively affecting markers of mitochondrial content and function, and others (90, 92–100).