In particular, we evaluated the prognostic relevance of two IHC markers: CD34 and B-cell lymphoma 2 (Bcl-2), which, although non-specific, can be useful diagnostic tools and were especially important in the pre-STAT6 era.[15] CD34 loss has been reported as a characteristic finding in dedifferentiated extra-CNS SFT.[16] Secondly, considered the prognostic relevance of mitotic count in this tumour entity, we wanted to evaluate if a count based on phosphorylated histone H3 (PHH3) IHC could improve its grading and prognostic capability compared to H&E-based mitotic count. This evidence concerns the gene STAT6 and neoplasm.