With the assistance of generalized additive models, we found that a higher VAS score of pruritus intensity was an independent risk factor for technique failure or death (HR, 1.64; 95% CI, 1.18 to 2.28; P = 0.003) after adjusting for daily urine amount, peritoneal solute clearance, peritoneal transport, body mass index, heart failure, fasting glucose, platelets, alanine transaminase, creatinine, and uric acid. The gene discussed is GPT; the disease is Pruritus.