TGFB1 and Hepatic fibrosis: To further analyze the effect of Paquinimod treatment on the development of liver fibrosis, we next analyzed the expression of genes for transforming growth factor (TGF)-β, C-C chemokine receptor type 2 (CCR2) and matrix metalloproteinase (MMP) 2 all of which are associated with cells involved in the development of fibrosis [10–12].