The tumor-immune interaction model, depicted in Fig 1A, can be perceived as three regulatory modules – (i) the core tumor along with the tumor infiltrated Tc cells (red box), (ii) the immune-stimulators consisting of M1 cells, TH1 cells, IL2 and IFN-γ cytokines (green box) and (c) the immune-suppressors consisting of M2 cells, TH2 cell, Treg cells and IL10 cytokines (orange box). The gene discussed is IL2; the disease is neoplasm.