The CSCs and the Cancer cells induce the production of immune-modulatory molecules such as IL-10, IL-13 and TGF-β that are conducive to the proliferation of the M2-Tumor Associated Macrophages (M2-TAM), the Type II T-helper (TH2) cells and the T-regulatory (Treg) cells [6, 7]. The gene discussed is IL10; the disease is neoplasm.