However, in randomized controlled studies of non-dialysis CKD patients with renal anemia conducted in Japan, no difference was found between the darbepoetin group (target Hb, 11.0–13.0 g/dL) and the rHuEPO group (target Hb, 9.0–11.0 g/dL) in terms of safety, including risk for CV events. Here, GSTM1 is linked to chronic kidney disease.