GSTM1 and hypertensive disorder: In the CREATE study, the target Hb value in the high Hb group was as high as 13.0–15.0 g/dL, and hypertension (defined as a systolic blood pressure of ≥ 160 mmHg) was reported as an AE in more patients in the high Hb group (20% of patients in the low Hb group vs. 30% in the high Hb group).