Even though NF patients are predisposed to variety of cancers, breast cancer risk was not confirmed until recently.15–17NF1 was first implicated in sporadic breast cancer by the initial comprehensive genome breast cancer studies where NF1 mutations were identified in 2–4% of breast cancers.18,19 Our analysis of the extensive METABRIC data set verified the NF1 mutation frequency, but also discovered NF1 shallow deletions in 25% of sporadic breast cancers. This evidence concerns the gene NFASC and cancer.