TXNIP and Familial prostate cancer: Additionally, we have recently shown that calcitriol induces non-canonical regulation of TXNIP in the prostate cancer cell line LNCaP [16], and that in HL-60 cells, i.e., the cell line in which the original identification was made, induction in TXNIP protein levels by 1,25(OH)2D3 depended on the availability of glucose in the culture medium [40].