Additionally, while TXNIP has been previously identified as a tumor suppressor and a vitamin D target gene, our results indicate that activation of TXNIP expression by calcitriol is not achieved in different BCa cell lines, and that in MCF-7 cells, the reduction in the TXNIP level by treatment is potentially due to rewiring of glucose metabolism, protein degradation, and cross-talk between VDR and ER signaling. Here, VDR is linked to neoplasm.