We found that both c-Cbl and CIN85 were significantly increased in CLL patients with respect to normal controls (c-Cbl **p < 0.01, CIN85 ****p < 0.0001; Figure 1B i-ii); no differences were observed between the two prognostic groups of CLL patients (SHM+/− and Zap70+/−; Figure 1B iii-vi). This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.