Mankai et al. showed that Y700 was lower phosphorylated in advanced BINET stage B CLL patients and that the disease progression was correlated with a specific threshold value of optical density ratio of ZAP70/c-Cbl.P: stage A patients were found to have a ratio <1 while stage B patients were shown to have a ratio ≥1. This evidence concerns the gene CBL and B-cell chronic lymphocytic leukemia.