CBL and B-cell chronic lymphocytic leukemia: Data obtained from 10 independent experiments allowed to show that in CLL B cells, expressing both IgM and IgD (Supplementary Figure 2A), c-Cbl was not subjected to ubiquitination (Figure 2A, c-Cbl lane), despite its high level of phosphorylation on Y700 after stimuli (Figure 2B), one of the major phosphorylation sites of active form of c-Cbl [21, 22].