BCR and B-cell chronic lymphocytic leukemia: By co-immunoprecipitation experiments, we found that, differently from what has been described for normal B cells [13, 14] (Supplementary Figure 1), CIN85 and c-Cbl were not constitutive associated in neoplastic B lymphocytes (compare Cnt n = 3 with CLL n = 20; CLL#1 and CLL#2; Figure 1C), neither upon anti-IgM BCR stimulation (Figure 1D).