As it is appreciable in Figure 5, in CLL patients with Cortactin overexpression, c-Cbl and Cortactin were constitutive associated (CLL#491 and CLL454; Figure 5) while, in patients with lower Cortactin expression the two proteins did not co-immunoprecipitate (CLL#223; Figure 5), independently from c-Cbl protein level. Here, CBL is linked to B-cell chronic lymphocytic leukemia.