INS and cancer: The up-regulated DEGs were enriched in protein processing in the endoplasmic reticulum, base excision repair, pentose and glucuronate interconversions, proteasome, and ascorbate and aldarate metabolism while the down-regulated DEGs were enriched in proteoglycans in cancer, the ErbB signaling pathway, bacterial invasion of epithelial cells, the insulin signaling pathway, and the neurotrophin signaling pathway.