Thus, the main purpose of this work is to investigate the efficacy of inhibitors of cytosolic and secreted PLA2, such as bromoenol lactone (BEL), methyl arachidonyl fluorophosphonate (MAFP) and aristolochic acid (AA) during infection (in vitro and in vivo) with L. (L.)amazonensis. The gene discussed is PLA2G2A; the disease is infection.