In this aspect, it was verified that BALB/c mice infected with L. (L.)amazonensis and treated with 10 nM or 30 nM of BEL exhibited decreased lesion size at 6, 7, and 8 weeks post-infection when compared with the infected control, an effect associated with reduced parasitism on the skin, but not in the lymph nodes (data not shown), suggesting that in vivo PLA2 may be responsible, at least in part, for the induction of pathology in a murine model of cutaneous leishmaniasis. This evidence concerns the gene PLA2G2A and cutaneous leishmaniasis.