To further investigate whether miR-876-5p targets vimentin to regulate HNSCC cell invasion and migration, we divided into four groups: miR-876-5p-NC co-transfection with vimentin-NC, miR-876-5p mimics co-transfection with vimentin overexpression, miR-876-5p-NC together with vimentin overexpression, and miR-876-5p mimics together with vimentin-NC. Here, VIM is linked to head and neck squamous cell carcinoma.