A trend for higher genetic effects on serum urate levels in individuals with eGFR <30 ml/min/1.73 m2 lends some support to the importance of intestinal ABCG2 function, but results from our interaction analysis with eGFR did not support the hypothesis that genetic effects of ABCG2 on serum urate become larger i.e. more important in individuals with CKD compared to the general population in a linear fashion. Here, ABCG2 is linked to chronic kidney disease.