ABCG2 and gout: We investigated whether genetic effects were more clearly discernible in joints across which temperature, weight pressure or usage strain may differ for the genome-wide significant urate-associated index SNPs at ABCG2 and SLC2A9. The SNP rs12498742 in SLC2A9 was significantly (p < 3.1E-03, 0.05/(2 * 8)) associated with gout affection in wrist and midfoot joints (Table 4).