Our mechanistic study revealed that dysregulated expression of TGFBR2 and USP15 is coordinately and simultaneously modulated by ectopic expression of MYEOV transcript, which absorbs, and thereby inhibits the free activity of, miR-30c-2-3p, leading to TGF-β-induced aggressive phenotype of NSCLC cells. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.