IHC assays were performed in 160 cases clinical in NSCLC specimens and results exhibited that the protein expression levels of TGFBR2, USP15, and nuclear-localized SMAD3 were significantly higher in MYEOV transcript-high expression group than those in the MYEOV transcript-low expression group (Fig. 7a, b), indicating that the transcript level of MYEOV significantly correlated with TGFBR2 and USP15 expression as well as the nuclear location of SMAD3 in clinical NSCLC. The gene discussed is SMAD3; the disease is non-small cell lung carcinoma.