MYEOV and non-small cell lung carcinoma: In addition, A549 cells with overexpressed MYEOV-cDNA or MYEOV-ATGmut increased the number of invaded NSCLC cells in Matrigel-coated Transwell assay and exhibit more aggressive phenotype in 3-D spheroid invasion assay, as compared with cell transduced with vector or MYEOV-miRmut (Fig. 4c, d).