Our mechanistic study revealed that dysregulated expression of TGFBR2 and USP15 is coordinately and simultaneously modulated by ectopic expression of MYEOV transcript, which absorbs, and thereby inhibits the free activity of, miR-30c-2-3p, leading to TGF-β-induced aggressive phenotype of NSCLC cells. The gene discussed is USP15; the disease is non-small cell lung carcinoma.