Minamino et al. demonstrated that genetically hyperphagic and obese Ay mice display increased p53 protein levels, increased reactive oxygen species (ROS) abundance, enhanced activity of senescence-associated β-galactosidase, and increased expression of genes encoding pro-inflammatory cytokines (such as tumor necrosis factor (Tnf) and chemokine (C-C motif) ligand 2 (Ccl2)) in epididymal WAT, as well as insulin resistance [71]. The gene discussed is TNF; the disease is Insulin resistance.