SEMA3E and Insulin resistance: By acting as a macrophage-attractant, the p53 target Sema3e elicits aggravated adipose tissue inflammation and insulin resistance under HFHS diet, effects that were strongly reduced in Fabp4-Cre/p53-lox mice in which the lack of p53 in adipocytes led to reduced Sema3e expression and secretion [67].