FFAR2 and hydrops fetalis: Maternal HF diet significantly decreased renal mRNA expression of Ffar3 (fold change (FC) = 0.27) and Ffar2 (FC = 0.28) compared with that in control, while the reduction of Ffar2 expression was partially prevented by prebiotic (FC = 0.48) or probiotic therapy (FC = 0.63) (Figure 2A).