KL and dementia: Klotho protein is predominantly secreted by the choroid plexus of the brain, and protects hippocampal neurons from amyloid and glutamate toxicity via the activation of an antioxidant enzymatic system, suggesting Klotho is necessary for oligodendrocyte maturation and myelin integrity.The Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion [68].