Finally, Rosner and colleagues identified an RKIP-regulated signaling pathway involving an HMGA2 (high mobility group AT-hook 2) - TET1 (ten-eleven translocation 1) - HOX (homeobox gene) axis in the epigenetic regulation of breast cancer cells and showed that 5-AzaC treatment was effective at inhibiting tumor cell invasion by targeting these genes [9]. Here, HMGA2 is linked to breast carcinoma.