MAPK1 and melanoma: Similarly, Das et al. reported that, in melanoma cell lines, MDA-9 (melanoma differentiation associated gene 9), a PDZ-domain (the postsynaptic density protein (PSD-95), discs-large tumor suppressor (Dlg), and tight junction protein-1 (ZO-1) containing scaffold protein that promotes melanoma progression and metastasis, can silence RKIP transcription by activating SNAIL expression through ERK1 and ERK2 (Mitogen-activated protein kinase 3 and 1, respectively) and NFκB signaling [30].