KRIT1 and famililal cerebral cavernous malformations: Cerebral cavernous malformations are characterized by the presence of vascular lesions that are most prevalent in the brain and can occur sporadically or through a familial condition from mutations in CCM1/KRIT1, CCM2/Malcavernin, or CCM3/PDCD10 [reviewed in (Chan et al, 2010; Riant et al, 2010; Fischer et al, 2013)].