In addition, forced expression of miR-214 enhanced Bcl-2 level, reduced Bax level and decreased fibronectin protein level in I/R-induced rat AKI model relative to that in sham group (Fig. 5e), suggesting that overexpression of miR-214 inhibited apoptosis and fibrosis in I/R-induced rat AKI model. This evidence concerns the gene FN1 and acute kidney injury.