In this regard, adoptive transfer of tumor-specific CD8+CD103+-T cells in the cognate tumor engrafted in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice and subsequent coengagement of TCR and TGFBR trigger CD103 expression on T-cell surface associated with acquisition of a strong cytotoxic capacity toward autologous tumor cells. This evidence concerns the gene ITGAE and neoplasm.