TGFB1 and neoplasm: GAS6 binds to the TAM receptor Axl on prostate cancer tumor cells which in turn induces expression of TGF-β1 and β2, this stimulates paracrine secretion (from osteoblasts) and autocrine secretion (from tumor cells) and leads to tumor cell dormancy through up-regulation of p27 an ubiquitous cell cycle inhibitor [102].