TNFSF11 and neoplasm: CXCL 12, integrins, osteopontin, vascular cell adhesion molecule-1 (VCAM-1), transforming growth factor beta (TGF-beta) and the receptor activator of nuclear factor kappa-b ligand (RANKL) are have been reported to influence the metastatic niche specificity for tumor type [69, 72].