SNAI2 and Familial prostate cancer: Inhibition of Epithelial Growth Factor receptor signaling causes re-expression of E-cadherin in cultured prostate cancer cells [92] via the transcription factors Snail [93] and/or Slug [94] is one described mechanism, the second being by direct interaction at the promoter site or via the transcriptional factors Snail, Slug and Twist [95].