NOTCH3 and neoplasm: To define the causative role of NOTCH3 expression in promoting ALDH1 activity that represents a universal functional marker of tumor stemness, chemoresistance, and metastasis [34, 39], we performed an ALDEOFLUOR assay in vMCF-7Raf-1 1GX and vMCF-7Raf-1 1GXCRISPR-NOTCH3 cells.