Significantly, forced expression of the mitotic Aurora kinase A (AURKA), which promotes stemness and breast cancer metastases [29], failed to restore the invasive capacity of NOTCH3-null vMCF-7Raf-1 cells, demonstrating that NOTCH3 oncogenic signaling is downstream of AURKA and is essential to inducing breast cancer cell invasiveness. The gene discussed is NOTCH3; the disease is breast cancer.