Immunofluorescence analysis showed a higher percentage of vMCF-7Raf-1 1GX-M cells expressing NOTCH3 than their matching vMCF-7Raf-1 1GX cells (Fig. 3f), suggesting that NOTCH3-expressing cancer cells exhibited a higher capacity to promote seeding and growth to distant organs. The gene discussed is NOTCH3; the disease is cancer.