Notably, several age-downregulated genes, such as Plxdc2 [18], Igf1, Igf2bp3, and Igf1r, and upregulated genes, such as Adam19 [19] and Tmem163 [20], have been linked to IGF signaling or type 2 diabetes. The gene discussed is IGF1R; the disease is type 2 diabetes mellitus.