Importantly, in cells co-treated with palbociclib, genetic or pharmacologic inhibition of autophagy with Spautin-1, liensinine, or 3-methyladenine (3-MA) also restored the effect of bortezomib on cell death induction in MCL cell lines Mino and Jeko-1 (Fig. 2d, left and Additional file 9: Figure S8) and on NOXA induction in MCL cell line Mino (Fig. 2d, right). This evidence concerns the gene PMAIP1 and mantle cell lymphoma.