Some studies have identified baseline renal function as a possible modifier of the discrimination ability of urinary NGAL as an AKI biomarker, with greater predictive ability in patients with eGFR ≥ 60 mL/min than in those with eGFR < 60 mL/min.[36, 37] This may be due to the less-functional nephron mass with a reduced ability to produce NGAL during renal insult. This evidence concerns the gene LCN2 and acute kidney injury.