These associations for species of LPE and ceramides were reported by Meikle et al.[33], in the study Australian diabetes, obesity and lifestyle, where these classes were significantly associated with the presence of type 2 diabetes (DT2) and pre-diabetes and observed by Tulipani et al. [16] in a study with insulin-resistant participants in the pre-diabetic stage, which confirmed correlations with circulating sphingolipids, including various specific ceramides. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.