In our application, we obtainedP(x)=P(TumorStage)⋅P(Yearsdiagnosistostudyentry)⋅P(Neighborhood)⋅P(Alcoholintake)⋅P(Copingstyle)⋅P(Education)⋅P(Age)⋅P(Smoke)⋅P(Insomnia)⋅P(Depression|Insomnia)⋅P(Sleep1|Insomnia,Depression)⋅P(Arthritis|Depression)⋅P(BMI|Smoke,Arthritis)⋅P(Sleep2|Depression,Sleep1)⋅P(QOLp|BMI,Sleep2,Arthritis)⋅P(QOLm|Depression,Sleep2)⋅P(Insulin|BMI)⋅P(CRP|BMI)⋅P(PA|Age,Sleep2,Insulin)(2)This decomposition converts the complex model comprising 19 variables into simpler components. This evidence concerns the gene CRP and major depressive disorder.