Recently, we reported that a DNA aptamer, a short and single-stranded DNA, directed against RAGE (RAGE aptamer) inhibited the binding of AGE to RAGE and attenuated the development and progression of streptozotocin-induced diabetic nephropathy in rats and deoxycorticosterone acetate/salt-induced renal injury in mice [17, 18]. The gene discussed is AGER; the disease is diabetic kidney disease.