Husser et al. reported that the ZFHX3 gene SNP rs12373097 was associated with AF recurrence in both PAF and persistent AF patients [9], while Park et al. reported that the ZFHX3 gene SNP rs2106261 was an independent predictor of good responders to RFCA among long-standing persistent AF patients [16]. The gene discussed is ZFHX3; the disease is atrial fibrillation.