WEE1 and breast cancer: Taking this one step further, Finetti et al. (2008) [29] focused on the expression of protein kinase genes, and defined a kinome signature (16 kinases) that could differentiate between basal (high kinome expression) and luminal A (low kinome expression) breast cancers, and furthermore could stratify luminal A breast cancers into Aa (lowest kinome expression) and Ab (higher kinome expression) sub-types.