Upon analyzing the Curtis Breast database, which profiles the expression of >19,273 genes in >2,000 cases, VRK1 was in the top 5% (Fig 7C, boxes 2,3,6–9) or 10% (Fig 7C, boxes 5 and 11) of genes that were upregulated in multiple sub-types of invasive breast carcinoma relative to normal breast tissue. The gene discussed is VRK1; the disease is invasive breast carcinoma.