SHBG and Renal insufficiency: The SHBG level gradually increases in aging men.34,35 Furthermore, the increase in SHBG levels is related to the age-dependent decline in circulating growth hormone or insulin-like growth factor level.25 Various chronic diseases (such as diabetes mellitus, coronary atherosclerosis, renal failure, and liver disease) in aging men are associated with decreased (F)T levels and increased SHBG.36–39 Therefore, our results indicate that MR-10 has the potential to improve men's health through the cooperative effects of increasing (F)T and decreasing SHBG.