We next asked whether tumor CNA burden was associated with outcome after adjusting for established prognostic variables, including Gleason sum score and the UCSF Cancer of the Prostate Risk Assessment (CAPRA) score (Cooperberg et al., 2005; Brajtbord et al., 2017) which combines PSA, Gleason score, percentage positive biopsy cores, clinical stage, and age (Figure 2c). The gene discussed is KLK3; the disease is cancer.