Upon irradiation, tumour cells and tumour-associated endothelial cells express a wide range of ‘novel’ antigens (called ‘neoantigens’) including immune regulatory molecules—major histocompatibility complex (MHC) class I, CD80, CD20, CD94; death receptors and apoptosis-associated molecules—Fas, FasL, TRAIL, phosphatidylserine; cell adhesion molecules—integrins (α2bβ3, α5β1), cadherins (E-cadherin and α-catenin), P-selectin, E-selectin, ICAM-1, and VCAM-1; ER molecules—BiP, calreticulin as reviewed by Corso et al. (2011). The gene discussed is CALR; the disease is neoplasm.